FoxP3 overexpression and CD1a+ and CD3+ depletion in anal tissue as possible mechanisms for increased risk of human papillomavirus‐related anal carcinoma in HIV infection
Identifieur interne : 000155 ( France/Analysis ); précédent : 000154; suivant : 000156FoxP3 overexpression and CD1a+ and CD3+ depletion in anal tissue as possible mechanisms for increased risk of human papillomavirus‐related anal carcinoma in HIV infection
Auteurs : M. Yaghoobi [Canada] ; S. Le Gouvello ; N. Aloulou ; C. Duprez- Dutreuil ; F. Walker [France] ; I. SobhaniSource :
- Colorectal Disease [ 1462-8910 ] ; 2011-07.
English descriptors
- Teeft :
- Ain3, Ain3 cancer, Anal, Anal biopsies, Anal canal, Anal cancer, Anal carcinoma, Anal condyloma, Anal mucosa, Anal tissue, Authors colorectal disease, Baseline, Biopsy, Carcinoma, Case group, Cd1a, Cell count, Cell counts, Coloproctology, Colorectal, Control group, Dysplasia, Foxp3, Great britain, Groupe henri chenevier, High prevalence, Hivinfected patients, Human virus, Infection, Infection increases, Invasive carcinoma, Local immunity, Lower grade dysplasia, Multiple regression analysis, Normal biopsies, Odds ratio, Papillomavirus infection, Peripheral blood, Regulatory cells, Risk factors, Roche diagnostics, Study period, Tissue cd1a.
Abstract
Aim We analysed local cellular and humoral immunity factors in the anal mucosa in an attempt to explain how HIV infection increases the risk of anal cancer in HPV‐infected patients. Method HIV‐positive cases and matched HIV‐negative controls with more than one recurrence of condylomas were included in a prospective study following treatment of the initial lesions. Patients were followed every 3 to 6 months for the development of anal intraepithelial neoplasia (AIN3) and cancer for up to 60 months. Tissue CD1a+, CD3+, CD4+, CD8+ cells and mRNAs of selected cytokines and chemokines were quantified and compared in patients with or without AIN3 or cancer using morphometric or immunohistochemistry analysis and qRT‐PCR. Results Sixty‐six individuals (22 patients and 44 controls) were included. In the case group, CD1a+ and CD3+ cell counts were significantly lower in biopsies from AIN3 and cancer specimens compared with those from AIN 1‐2 or normal biopsies (P < 0.0001). A CD1a+ count of < 10/mm was predictive of AIN3 and cancer (Odds ratio = 9.4, 95% CI: 5.4–18.3, P < 0.0001). IL‐8 and IL23 levels were significantly higher in cancer than in non‐cancer tissues regardless of HIV status (P = 0.02). FoxP3 expression was significantly higher in HIV‐infected cases than in controls with AIN3/cancer (P < 0.04). Conclusion Depletion of CD1a+ and CD3+ cells and overexpression of FoxP3 in the anal mucosa appear likely to contribute to the risk of HPV‐related anal cancer in HIV‐infected patients. Furthermore, overexpression of IL‐8 and IL‐23 in the anal mucosa might be responsible for the development of this cancer regardless of HIV status.
Url:
DOI: 10.1111/j.1463-1318.2010.02283.x
Affiliations:
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Walker</name></author><author><name sortKey="Sobhani, I" sort="Sobhani, I" uniqKey="Sobhani I" first="I." last="Sobhani">I. 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Yaghoobi</name><affiliation wicri:level="4"><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation></affiliation></author><author><name sortKey="Le Gouvello, S" sort="Le Gouvello, S" uniqKey="Le Gouvello S" first="S." last="Le Gouvello">S. Le Gouvello</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Créteil</wicri:noCountry></affiliation></author><author><name sortKey="Aloulou, N" sort="Aloulou, N" uniqKey="Aloulou N" first="N." last="Aloulou">N. Aloulou</name><affiliation><wicri:noCountry code="subField">Créteil</wicri:noCountry></affiliation></author><author><name sortKey="Duprez Dutreuil, C" sort="Duprez Dutreuil, C" uniqKey="Duprez Dutreuil C" first="C." last="Duprez- Dutreuil">C. Duprez- Dutreuil</name><affiliation><wicri:noCountry code="subField">Créteil</wicri:noCountry></affiliation></author><author><name sortKey="Walker, F" sort="Walker, F" uniqKey="Walker F" first="F." last="Walker">F. Walker</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>AP‐HP, Groupe Bichat Claude Bernard, Service d’anatomie pathologie, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Sobhani, I" sort="Sobhani, I" uniqKey="Sobhani I" first="I." last="Sobhani">I. Sobhani</name><affiliation></affiliation><affiliation><wicri:noCountry code="subField">Créteil</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Colorectal Disease</title><title level="j" type="alt">COLORECTAL DISEASE</title><idno type="ISSN">1462-8910</idno><idno type="eISSN">1463-1318</idno><imprint><biblScope unit="vol">13</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="768">768</biblScope><biblScope unit="page" to="773">773</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2011-07">2011-07</date></imprint><idno type="ISSN">1462-8910</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1462-8910</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Ain3</term><term>Ain3 cancer</term><term>Anal</term><term>Anal biopsies</term><term>Anal canal</term><term>Anal cancer</term><term>Anal carcinoma</term><term>Anal condyloma</term><term>Anal mucosa</term><term>Anal tissue</term><term>Authors colorectal disease</term><term>Baseline</term><term>Biopsy</term><term>Carcinoma</term><term>Case group</term><term>Cd1a</term><term>Cell count</term><term>Cell counts</term><term>Coloproctology</term><term>Colorectal</term><term>Control group</term><term>Dysplasia</term><term>Foxp3</term><term>Great britain</term><term>Groupe henri chenevier</term><term>High prevalence</term><term>Hivinfected patients</term><term>Human virus</term><term>Infection</term><term>Infection increases</term><term>Invasive carcinoma</term><term>Local immunity</term><term>Lower grade dysplasia</term><term>Multiple regression analysis</term><term>Normal biopsies</term><term>Odds ratio</term><term>Papillomavirus infection</term><term>Peripheral blood</term><term>Regulatory cells</term><term>Risk factors</term><term>Roche diagnostics</term><term>Study period</term><term>Tissue cd1a</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Aim We analysed local cellular and humoral immunity factors in the anal mucosa in an attempt to explain how HIV infection increases the risk of anal cancer in HPV‐infected patients. Method HIV‐positive cases and matched HIV‐negative controls with more than one recurrence of condylomas were included in a prospective study following treatment of the initial lesions. Patients were followed every 3 to 6 months for the development of anal intraepithelial neoplasia (AIN3) and cancer for up to 60 months. Tissue CD1a+, CD3+, CD4+, CD8+ cells and mRNAs of selected cytokines and chemokines were quantified and compared in patients with or without AIN3 or cancer using morphometric or immunohistochemistry analysis and qRT‐PCR. Results Sixty‐six individuals (22 patients and 44 controls) were included. In the case group, CD1a+ and CD3+ cell counts were significantly lower in biopsies from AIN3 and cancer specimens compared with those from AIN 1‐2 or normal biopsies (P < 0.0001). A CD1a+ count of < 10/mm was predictive of AIN3 and cancer (Odds ratio = 9.4, 95% CI: 5.4–18.3, P < 0.0001). IL‐8 and IL23 levels were significantly higher in cancer than in non‐cancer tissues regardless of HIV status (P = 0.02). FoxP3 expression was significantly higher in HIV‐infected cases than in controls with AIN3/cancer (P < 0.04). Conclusion Depletion of CD1a+ and CD3+ cells and overexpression of FoxP3 in the anal mucosa appear likely to contribute to the risk of HPV‐related anal cancer in HIV‐infected patients. Furthermore, overexpression of IL‐8 and IL‐23 in the anal mucosa might be responsible for the development of this cancer regardless of HIV status.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Ontario</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Aloulou, N" sort="Aloulou, N" uniqKey="Aloulou N" first="N." last="Aloulou">N. Aloulou</name><name sortKey="Duprez Dutreuil, C" sort="Duprez Dutreuil, C" uniqKey="Duprez Dutreuil C" first="C." last="Duprez- Dutreuil">C. Duprez- Dutreuil</name><name sortKey="Le Gouvello, S" sort="Le Gouvello, S" uniqKey="Le Gouvello S" first="S." last="Le Gouvello">S. Le Gouvello</name><name sortKey="Sobhani, I" sort="Sobhani, I" uniqKey="Sobhani I" first="I." last="Sobhani">I. Sobhani</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Yaghoobi, M" sort="Yaghoobi, M" uniqKey="Yaghoobi M" first="M." last="Yaghoobi">M. Yaghoobi</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Walker, F" sort="Walker, F" uniqKey="Walker F" first="F." last="Walker">F. Walker</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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